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本研究中除设立正常对照组，四氯化碳（ＣＣｌ４）对照组外，尚设立２４０ｍｍｏｌ／Ｌ牛磺酸预投组（只在染毒前给予）和２４０ｍｍｏｌ／Ｌ牛磺酸同投组（只在染毒同时给予）来对照考察８０ｍｍｏｌ／Ｌ和２４０ｍｍｏｌ／Ｌ牛磺酸双投（染毒前及染毒过程中均给予）对５００ｍｇ／ＫｇＣＣｌ４经口染毒，２次／周，持续５周实验动物的干预作用。结果如下：１．２４０ｍｍｏｌ／Ｌ牛磺酸双投对Ｃａ２＋－Ｍｇ２＋－ＡＴＰａｓｅ活性有部分保护作用，使其达到对照组的７４．４８％；对Ｃａｍ活性亦有明显的保护作用，并使线粒体钙含量显著降低；８０ｍｍｏｌ／Ｌ双投，２４０ｍｍｏｌ／Ｌ预投和２４０ｍｍｏｌ／Ｌ同投均未有明确的干预作用。２．８０ｍｍｏｌ／Ｌ和２４０ｍｍｏｌ／Ｌ牛磺酸双投作用存在明显差异。２４０ｍｍｏｌ／Ｌ双投明显地防止了Ｃａ２＋－Ｍｇ２＋－ＡＴＰａｓｅ和Ｃａｍ活性的抑制，对线粒体钙含量亦有显著的降低作用，而８０ｍｍｏｌ／Ｌ牛磺酸未见此效果。３．２４０ｍｍｏｌ／Ｌ牛磺酸双投和保护作用明显，优于２４０ｍｍｏｌ／Ｌ同投；２４０ｍｍｏｌ／Ｌ牛磺酸预投的效果不明显。故研究提示应重视牛磺酸干预作用的时效性和量效性。
In addition to the normal control group, carbon tetrachloride (CCl4) control group, 240mmol / L taurine pre-injection group (only given before exposure) and 240mmol / L taurine co-injection group Only given at the same time exposure) to control 80mmol / L and 240mmol / L taurine double vote (both before and during exposure to poisoning) 500mg / KgCCl4 oral administration, 2 times / week for 5 Week experimental animal intervention. The results are as follows: 1.240mmol / L taurine double cast on Ca2 + -Mg2 + -ATPase activity in part to protect the control group reached 74.48%; Cam activity also has a significant protective effect, and mitochondrial calcium Content significantly reduced; 80mmol / L double cast, 240mmol / L pre cast and 240mmol / L with the vote did not have a clear intervention. 2.80mmol / L and 240mmol / L taurine double-vote there is a significant difference. 240mmol / L double cast significantly prevented the inhibition of Ca2 + -Mg2 + -ATPase and Cam activity, but also significantly reduced the mitochondrial calcium content, whereas 80mmol / L taurine did not show this effect. 3.240mmol / L taurine double cast and the protective effect was significantly better than 240mmol / L the same cast; 240mmol / L taurine pre-cast the effect is not obvious. Therefore, research tips should pay attention to the effect of taurine intervention time and dose-effectiveness.