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目的 探索并验证一种安全有效、简便易行、能够明显缩短中期妊娠引产时间的新方法。方法 在 4家医疗单位中 ,选择 14～ 2 2孕周需要引产的健康妊娠妇女共 12 2例 ,随机分成 2组。研究组共 64例 ,先按常规行羊膜腔穿刺注入依沙吖啶 10 0mg ,术毕即于阴道后穹窿处放置米索前列醇 2片 (0 .4mg/片 ) ;对照组共5 8例 ,以甲硝唑片 2片 (0 .4g/片 )取代米索前列醇片。结果 研究组单次引产成功率 (96.9% )高于对照组 (82 .8% ) ,差异有显著性 (P <0 .0 1) ;研究组胎儿排出时间为 (2 8.8± 17.2 )h ,短于对照组的 (5 0 .2± 10 .9)h ,差异有显著性 (P <0 .0 0 1) ;与对照组相比 ,研究组产后出血较少 ,胎盘排出、宫内组织残留以及产后恢复等均未受明显影响 ,无一例出现强直性宫缩 ,也不增加各种并发症和不良反应的发生率。结论 米索前列醇配伍依沙吖啶引产法明显提高单次引产的成功率 ,大大缩短引产所需的时间。只要严格掌握适应证 ,这是一种安全、高效、廉价、方便的引产方法
Objective To explore and validate a new safe and effective, simple and easy method that can significantly shorten the time of induction of labor in mid-term pregnancy. Methods A total of 122 healthy pregnant women who needed induction of labor during the 14 ~ 22 gestational weeks were randomly divided into 2 groups. The study group consisted of 64 patients. First, amniocin 10 10 mg was administered by amniocentesis. 2 patients (0.4 mg / tablet) of misoprostol were placed at the posterior vaginal fornix. A total of 58 patients , With metronidazole tablets 2 (0.4 g / tablet) to replace misoprostol tablets. Results The success rate of single induction of labor (96.9%) in study group was higher than that in control group (82.8%), the difference was significant (P <0.01). The fetal discharge time in study group was (2 8.8 ± 17.2) Shorter than the control group (50.2 ± 10.9) h, the difference was significant (P <0.01); compared with the control group, the study group less postpartum hemorrhage, placental discharge, intrauterine tissue Residual and postpartum recovery, etc. were not significantly affected, no case of tonic contractions, nor increase the incidence of various complications and adverse reactions. Conclusion Misoprostol combined with ethacridine induction significantly improves the success rate of single induction and shortens the time needed to induce labor. As long as the indications are strictly controlled, this is a safe, efficient, cheap and convenient method of induction of labor