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目的：对呼吸监护病区分离的１３５株绿脓杆菌进行耐药性监测，为合理应用抗菌药物提供准确可靠的依据。方法：１３种抗菌药物敏感性试验采用纸片扩散法，用Ｎｉｔｒｏｃｅｆｉｎ纸片检测β－内酰胺酶。结果：下呼吸道感染致病菌中绿脓杆菌的检出率为１８７％。１３５株绿脓杆菌对各种抗菌药物呈不同程度的耐药，耐药性较低的有妥布霉素（１６．４％）、君刻单（２３．３％）及舒普深（２９．０％）。从普通病房与加强护理病房（ＩＣＵ）分离出的绿脓杆菌对各种抗菌药物的敏感性也有所不同，君刻单和妥布霉素不管是对普通病房还是ＩＣＵ分离的菌株均具有较高的敏感性，两者比较差异无显著性（Ｐ＞００５）。结论：应重视当前病房致病菌的变化及其耐药性监测，抗菌药物的选择应在体外细菌药敏试验指导下进行，必要时联合用药可望进一步提高临床疗效
OBJECTIVE: To monitor the drug resistance of 135 strains of Pseudomonas aeruginosa isolated from respiratory care wards and provide an accurate and reliable basis for rational use of antibiotics. METHODS: Thirteen antimicrobial susceptibility tests were performed using the disk diffusion method with beta-lactamase using Nitrocefin paper. Results: The detection rate of Pseudomonas aeruginosa in lower respiratory tract infection was 18.7%. 135 strains of Pseudomonas aeruginosa showed various degrees of resistance to various antimicrobial agents, including tobramycin (16.4%), Jun Keshan (23.3%) and Shu Pushen (29) .0%). Pseudomonas aeruginosa isolated from general ward and intensive care unit (ICU) also had different sensitivity to various antimicrobial agents. Junk single and tobramycin both had higher rates of isolation for general ward and ICU The sensitivity was not significant (P> 005). Conclusion: At present, attention should be paid to the change of pathogenic bacteria in hospital wards and the monitoring of their drug resistance. The selection of antibacterial drugs should be conducted under the guidance of bacterial susceptibility test in vitro. If necessary, the combination therapy is expected to further improve the clinical efficacy