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观察到环肽类抗生素多粘菌素Ｂ对小鼠肉瘤Ｓ１８０细胞增殖具有显著抑制作用，半数有效抑制浓度（ＩＣ５０）为８．９５×１０５ＩＵ·Ｌ－１。用毛细管柱气相色谱法分析了多粘菌素Ｂ作用于Ｓ１８０细胞２４ｈ后膜脂肪酸组成的变化，发现磷脂的花生四烯酸（Ｃ２０：４）显著减少，中性脂的硬脂酸（Ｃ１８：０）增多，油酸（Ｃ１８：１）减少，硬脂酸与油酸的比值（Ｃ１８：０／Ｃ１８：１）升高．提示多粘菌素Ｂ对Ｓ１８０细胞增殖的抑制与膜脂肪酸组成的变化有关。
Cyclic antibiotic polymyxin B was found to inhibit the proliferation of murine sarcoma S180 cells significantly. The IC50 value was 8.95 × 105 IU · L-1. The changes of membrane fatty acid composition of S180 cells treated with polymyxin B were analyzed by capillary gas chromatography. The results showed that the content of arachidonic acid (C20: 4) of phospholipids was significantly decreased, the content of stearic acid (C18: 0) increased, oleic acid (C18: 1) decreased, stearic acid and oleic acid ratio (C18: 0 / C18: 1) increased. Tip polymyxin B on S180 cell proliferation inhibition and membrane fatty acid composition changes.