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采用包夹聚合法 ,将硅小球同硅烷化试剂反应制得乙烯基硅胶 ,然后将该乙烯基硅胶同经十一烯酰氯、4 甲基苯甲酰氯衍生的纤维素共聚 ,制备出含不同官能团的聚合物包夹硅基的键合型纤维素 (4 甲基苯甲酸酯 )类手性固定相。分别以正己烷 /异丙醇、正己烷 /四氢呋喃为流动相 ,对此键合型手性固定相的手性识别能力进行了评价。为了与同类型的涂敷型纤维素 (4 甲基苯甲酸酯 )手性固定相作比较 ,合成了涂敷型纤维素(4 甲基苯甲酸酯 )手性固定相。结果表明 ,键合型纤维素 (4 甲基苯甲酸酯 )手性固定相具有一定的手性识别能力 ,可以拆分所研究的 6种手性化合物中的 4种。
Polymerization using silica gel method, the reaction of silica beads with a silylating agent to obtain a vinyl silica gel, and then the vinyl silica with undecylenoyl chloride, 4 methyl benzoyl chloride derived cellulose copolymerization, prepared with different The functional group of the polymer encapsulates silicon-based bonded cellulose (4 methyl benzoate) -like chiral stationary phase. The chiral recognition ability of the bonded-type chiral stationary phase was evaluated by n-hexane / isopropanol and n-hexane / tetrahydrofuran respectively. Coated cellulose (4-methylbenzoate) chiral stationary phases were synthesized for comparison with the same type of coated cellulose (4-methylbenzoate) chiral stationary phases. The results show that the bonded-type cellulose (4-methylbenzoate) chiral stationary phase has some chiral recognition ability, and four of the six chiral compounds studied can be resolved.