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目的探讨CYP1A1、CYP2E1、PON2148、MTHFR基因多态性与低出生体重儿(LBW)易感性的关系。方法根据纳入排除标准全面检索万方、Pub Med、Web of Science、EMBASE、中国生物医学文献数据库和CNKI等数据库相关的文献,收集包括对氧磷酶基因(PON2 148),细胞色素(CYP1A1、CYP2E1),亚甲基四氢叶酸还原酶(MTHFR)基因与LBW的关联性的研究。应用Revman 5.3软件,按照文献的异质性,采用固定效应模型或随机效应模型对数据进行meta分析。结果共纳入7篇文献进行meta分析,其中中文6篇,英文1篇。关于PON2 148与低出生体重儿的文献3篇,MTHFR与低出生体重儿的文献2篇,CYP1A1、CYP2E1与低出生体重儿的文献4篇。母亲携带PON2 148基因型Gly148Gly/Ala148Gly新生儿低出生体重的关联差异无统计学意义(OR=1.35,95%CI:0.86~2.13,P=0.19);母亲携带MTHFR基因型CT/TT新生儿低出生体重的关联差异无统计学意义(OR=1.19,95%CI:0.80~1.76,P=0.40);母亲携带CYP1A1基因多态性与低出生体重的关联差异无统计学意义(OR=1.55,95%CI:0.92~2.62,P=0.10);母亲携带CYP2E1基因多态性与低出生体重的关联差异有统计学意义(OR=1.67,95%CI:1.03~2.72,P=0.04)。新生儿携带CYP2E1基因多态性与低出生体重儿的关联差异无统计学意义(OR=1.47,95%CI:0.93~2.33,P=0.10)。结论母亲CYP1A1、CYP2E1、PON2 148、MTHFR基因和新生儿CYP1A1、CYP2E1基因是新生儿低出生体重发生的危险因素。
Objective To investigate the relationship between genetic polymorphisms of CYP1A1, CYP2E1, PON2148 and MTHFR and susceptibility to low birth weight infants (LBW). Methods According to the inclusion criteria, a comprehensive database including PON2 148, cytochromes (CYP1A1, CYP2E1 ), Methylenetetrahydrofolate reductase (MTHFR) gene and LBW correlation study. Using Revman 5.3 software, a meta-analysis of the data was performed using a fixed-effects model or a random-effects model according to the heterogeneity of the literature. Results A total of 7 articles were included in the meta-analysis, including 6 in Chinese and 1 in English. There are 3 literatures about PON2148 and low birth weight infants, 2 articles about MTHFR and low birth weight infants, 4 articles about CYP1A1, CYP2E1 and low birth weight infants. There was no significant difference in the low birth weight of mothers carrying PON2 148 genotype Gly148Gly / Ala148Gly (OR = 1.35, 95% CI: 0.86-2.13, P = 0.19). The mothers carrying MTHFR genotype CT / TT neonates were low (OR = 1.19, 95% CI: 0.80-1.76, P = 0.40). There was no significant difference in the association of CYP1A1 gene polymorphism with low birth weight (OR = 1.55, 95% CI: 0.92-2.62, P = 0.10). The correlation between CYP2E1 gene polymorphism and low birth weight in mothers was statistically significant (OR = 1.67,95% CI: 1.03-2.72, P = 0.04). Neonatal CYP2E1 genetic polymorphism and low birth weight infants no significant difference (OR = 1.47,95% CI: 0.93 to 2.33, P = 0.10). Conclusion Mothers CYP1A1, CYP2E1, PON2 148, MTHFR gene and neonatal CYP1A1, CYP2E1 gene are risk factors of neonatal low birth weight.