Intervention Timing and Effect of P J34 on Astrocytes During Oxygen-glucose Deprivation/reperfusion

• 作 者: 蔡川 张睿 黄巧英 曹旭 邹良玉 褚晓凡
• 机 构: DepartmentofNeurology,ResearchCentreforNeuralEngineering
• 出 处: 华中科技大学学报：医学英德文版
• 发表日期: 2015年3期
• 关键词: 缺血再灌注损伤 星形胶质细胞 细胞死亡 核糖 caspase 细胞存活率 保护作用 氧 PARP-1 inhibitor PJ34 primarycorti
• 基金项目: This work was supported by the National Natural Science Foundation of China （No. 30971024）. The authors thank Dr. Yun-hai QIU and Dr. Wei-jiao XIE （Research Centre for Neural Engineering, Institute of

Poly(ADP-ribose) polymerase-1(PARP-1) plays as a double edged sword in cerebral ischemia-reperfusion, hinging on its effect on the intracellular energy storage and injury severity, and the prognosis has relationship with intervention timing. During ischem