论文部分内容阅读
Objective To discuss the effects of FRUCTUS MUME on SOD activity and MDA content in mice colon tissue with ulcerative colitis (UC).Methods Mice were given 3% DSS solution; UC model of mice was established.Mice in normal group and model group were given 0.33 mL normal saline by gavage; mice in low-,middleand high-dosage groups of FRUCTUS MUME were given the designed dosage.Administration was carried out once every day with continuous 10 d.During this period,occult blood test was carried out; and the fecal character was observed for DAI evaluation; morphological score of colon tissue was evaluated by both naked eye and microscope observation.The SOD activity and MDA content in mice colon tissue were detected.Results There was no gross blood stool in middleand high-dosage groups of FRUCTUS MUME,and loose stool could be observed.DAI in low-,middleand high-dosage groups reduced and had extremely significant differences with that in model group (P<0.01).In high-dosage group of FRUCTUS MUME,mucosal erosion was not serious with slight hyperaemia and edema.SOD activities in middleand high-dosage groups were both significantly higher than that in model group,having extremely significant differences (P<0.01).Middle-dosage group had significant differences with normal group (P<0.05); and high-dosage group showed no significant differences with normal group (P>0.05).MDA contents in middleand high-dosage groups were significantly lower than that in model group,having extremely significant differences (P<0.01).Conclusions Free radical had close relationship with UC in colic injury.According to the pathological process of UC,FRUCTUS MUME had significant curative effects on UC through reducing the MDA content and enhancing the SOD activity of lesion tissues.