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胆、肾结石形成、骨的钙化和血管粥样硬化等生物体内许多矿化过程的机理非常复杂,有众多组分参与,临床发现生物体矿化异常时氢离子浓度明显偏离正常,尿结石患者的尿液通常pH低。本题研究pH值对金属配合物定量关系及推测它在生物矿化中的作用。选择同时具有酸碱平衡、沉淀平衡、配位平衡的多相化学平衡系统,具有氢氧化铜固体、四氨合铜(Ⅱ)配离子、铜(Ⅱ)离子、氢离子、氢氧根离子、氨的多化学组成为研究对象,通过将高等数学介入化学计算法,从理论上推出pH值对多组分多相化学平衡转换公式,通过计算机Excel XP软件转换函数式与图像和验证可见分光光度法的化学实验手段。结果,有配位剂时,pH显然能影响沉淀与配位转化的多相化学平衡。pH值低时仅有沉淀,且有固定的pH值,足以生成最大配合物的浓度,与配位剂的酸常数pKa相等。推测由于配位剂均是路易斯碱,当尿液偏碱性时有利于形成配合物而不利于形成矿化,生物体液具有不断更新流动的特点,使金属离子更容易以配合物的形式排出体外,则不易发生结石。
Bile, kidney stone formation, bone calcification and vascular atherosclerosis and other organisms in many mineralization process is very complex mechanism, there are many components involved in the clinical discovery of abnormal mineralization of the organism hydrogen ion concentration significantly deviated from the normal urinary calculus patients The urine is usually low in pH. This issue studies the quantitative relationship between pH and metal complexes and speculate on its role in biomineralization. A multiphasic chemical equilibrium system with acid-base balance, precipitation equilibrium and coordination equilibrium is selected, and a copper hydroxide solid, a copper (II) complex ion, a copper (II) ion, a hydrogen ion, a hydroxide ion, Ammonia multi-chemical composition of the object of study, through the higher mathematics involved in stoichiometry, the theoretical launch of the multi-component pH multi-phase chemical equilibrium conversion formula, through the computer Excel XP software conversion function and image and verify the visible spectrophotometry France’s chemical experiment means. As a result, in the presence of complexing agents, it is clear that pH can affect the heterogeneous chemical equilibrium of precipitation and coordination conversion. Only a low pH precipitate, and a fixed pH, sufficient to generate the maximum concentration of the complex, and complexing agent acid constant pKa equal. Presumably because the complexing agent is Lewis base, when the urine is alkaline is conducive to the formation of complexes and is not conducive to the formation of mineralization, biological fluid has the characteristics of the constant renewal of flow, so that the metal ions more easily excreted in the form of complexes , Is not prone to stones.