论文部分内容阅读
将120例DN患者随机分为观察组和对照组各60例,两组患者均给予基础降糖治疗,观察组患者加用α-硫辛酸;分析比较治疗前后两组患者各项生理指标的变化。结果:治疗后,对照组总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FBG)、糖化血红蛋白(HbA_(1c))、肌酐(CREA)、血管内皮生长因子(VEGF)、尿液中足细胞标志蛋白(PCX)及尿素(UREA)水平与治疗前相比差异不明显(P>0.05),观察组上述指标均显著降低(P<0.05),且低于对照组,差异有统计学意义(P<0.05)。结论:α-硫辛酸能够减少PCX的脱落,降低VEGF水平,从而减轻肾小球足细胞的损伤或减少其凋亡,对DN患者发挥治疗作用。
120 cases of DN patients were randomly divided into observation group and control group of 60 cases, both groups were given basic hypoglycemic therapy, observation group patients with α-lipoic acid; analysis of the two groups before and after treatment of the changes in the various physiological indicators . Results After treatment, TC, TG, FBG, HbA 1c, CREA, VEGF, The levels of PCX and UREA were not significantly different from those before treatment (P> 0.05). The above indexes in the observation group were significantly lower (P <0.05) and lower than those in the control group Significance (P <0.05). CONCLUSION: Alpha-lipoic acid can reduce PCX shedding and decrease VEGF level, thereby reducing glomerular podocyte injury or reducing apoptosis and exerting a therapeutic effect on DN patients.