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目的考察大剂量静脉用丙种球蛋白(IV IG)在病毒性脑膜炎的治疗中是否疗效显著。方法将收治的260例病毒性脑膜炎患儿随机分为治疗组(130例)和对照组(130例),给予对照组患者实施降颅压、对症支持治疗以及应用莪术油、病毒唑、干扰素等进行常规治疗,治疗组则在此基础上增加静脉注射IV IG(200～400mg/(kg.d)3d。比较两组5d、10d1、5d的治愈率及症状的恢复时间。结果治疗组各症状恢复时间及住院日均比对照组短,差异均有显著性意义(P均<0.001)。15d治愈率两组间差异无显著性意义,但5d、10d的治愈率治疗组明显高于对照组,差异有显著性意义(P<0.05)。结论大剂量静脉注射IV IG在病毒性脑膜炎治疗中疗效显著。
Objective To investigate whether high-dose intravenous gamma globulin (IVIG) is effective in the treatment of viral meningitis. Methods A total of 260 children with viral meningitis were randomly divided into treatment group (130 cases) and control group (130 cases). Patients in the control group were treated with intracranial pressure, symptomatic and supportive treatment, and Curcuma oil, Ribavirin, interference And other conventional treatment, the treatment group is based on the addition of intravenous IV IG (200 ~ 400mg / (kg.d) 3d .Comparison of two groups 5d, 10d1, 5d cure rate and recovery time of symptoms.Results The treatment group The recovery time of each symptom and hospitalization day were shorter than that of the control group (P <0.001), and the cure rate of 15d had no significant difference between the two groups, but the cure rate of 5d and 10d was significantly higher than that of the control group (P <0.05) .Conclusion High dose intravenous IV IG is effective in the treatment of viral meningitis.