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类风湿性关节炎(RA)是一种慢性、全身性炎性多关节炎,主要累及手、足等小关节,也可累及任何有滑膜的关节。一般认为其发病率为1.4％,女性多于男性,以25～55岁最常见。本文就近年来RA治疗的某些进展综述如下: 一、诊断与疗效标准 目前多用美国风湿病学会(ARA)的诊断标准:(1)关节晨僵;(2)至少有一个关节压痛或活动痛;(3)一个关节有软组织肿胀或积液;(4)至少有另一关节软组织肿胀或积液;(5)对称性关节肿胀,即同一关节左右同时受累;(6)皮下结节常在骨突处、伸面及关节附近出现;(7)典型的放射学改变,并包括关节端的脱钙,但退行性病变不能除外RA;(8)血清类风湿因子(RF)阳性;(9)滑液粘液蛋白形成不佳;(10)滑膜活检符合RA改变;(11)类风湿结节活检呈典型病理改变。上述2
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory polyarthritis involving the small joints of the hands and feet, but also of any synovial joint. Generally considered the incidence of 1.4%, more women than men, 25 to 55 years of age the most common. In this paper, some advances in the treatment of RA in recent years are summarized as follows: First, the diagnostic and efficacy criteria At present, with the American College of Rheumatology (ARA) diagnostic criteria: (1) joint morning stiffness; (2) at least one joint tenderness or active pain; (3) a joint with soft tissue swelling or effusion; (4) at least one other joint soft tissue swelling or effusion; (5) symmetrical joint swelling, the same joint left and right involvement; (6) subcutaneous nodules often bone (7) Typical radiological changes, including decalcification of the articular tip, but not degenerative disease except RA; (8) Serum rheumatoid factor (RF) positive; (9) (10) synovial biopsy in line with RA changes; (11) rheumatoid nodules biopsy showed a typical pathological changes. Above 2