论文部分内容阅读
自从1964年Terry等和Grey等报道IgG存在4种亚类以来,IgG亚类异常及其在一些疾病中的意义逐渐引起人们的重视,现复习文献介绍如下.一、生物学(一)基因位置IgG亚类的基因组的控制和(或)差别的研究虽未深入到区分蛋白质差异的水平,但在第14对染色体上控制Ig和亚类重链的基因的相对位置已被确定(见图);了解这一点对理解IgG_2和(或)IgG_4缺陷常伴IgA缺陷等现象有所帮助,因为这些Ig基因紧密连锁,对一基因组、转录、
Since the classification of IgG into four subtypes by Terry et al. And Gray et al. In 1964, the abnormalities of IgG subclasses and their significance in some diseases have drawn increasing attention. The review of the literature is as follows. Although the study of the control and / or differences in the IgG subclass genomes has not gone deep into discriminating between protein differences, the relative positions of genes controlling Ig and subclass heavy chains on chromosome 14 have been determined (see figure) ; Understanding this is helpful to understand the phenomenon of IgG2 and / or IgG4 defects often accompanied by IgA deficiency, because these Ig genes are closely linked to a genome, transcription,