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目的探讨低蛋白血症与早发型重度子痫前期妊娠结局的相关性。方法 97例早发型重度子痫前期患者随机分为A组(低蛋白血症组)和B组(非低蛋白血症组),通过比较两组终止妊娠时间、并发症、新生儿出生体重、窒息发生率、围生儿死亡发生率等来评价低蛋白血症对重度子痫前期患者妊娠结局的影响。结果 A组治疗时间、终止妊娠孕周明显低于B组,两组差异有统计学意义(P<0.05);A组新生儿出生体重明显低于B组,围生儿死亡率明显高于B组,两组差异有统计学意义(P<0.05);A组产妇心功能不全、肝肾功损害、胸腹水和胎盘早剥发生率明显高于B组,两组差异有统计学意义(P<0.05)。结论早发型重度子痫前期的孕妇合并低蛋白血症,对孕妇和胎儿会产生极大影响,孕妇并发症多且围生儿死亡率高,应密切严格监视从而指导治疗。
Objective To investigate the correlation between hypoalbuminemia and early pregnancy severe preeclampsia outcome. Methods Ninety - seven patients with early - onset severe preeclampsia were randomly divided into group A (hypoproteinemia group) and group B (non - hypoproteinemia group). By comparing the time of termination of pregnancy, complications, birth weight, The incidence of asphyxia, the incidence of perinatal death, etc. to evaluate the impact of hypoproteinemia on pregnancy outcome in patients with severe preeclampsia. Results The treatment time and the gestational age at termination of pregnancy in group A were significantly lower than those in group B, with significant difference between the two groups (P <0.05). The birth weight of newborns in group A was significantly lower than that in group B and the perinatal mortality was significantly higher than that in group B (P <0.05). The incidence of heart failure, liver and kidney damage, pleural, ascites and placental abruption in group A was significantly higher than that in group B (P <0.05). The difference between the two groups was statistically significant (P <0.05). Conclusions Pregnant women with early-onset severe preeclampsia combined with hypoproteinemia have a great impact on pregnant women and fetus. Pregnant women with multiple complications and high perinatal mortality should be closely monitored to guide the treatment.