Screening compounds against HCV based on MAVS/IFN-β pathway in a replicon mode

• 作 者: Qiu-Xia Fu Li-Cui Wang Shuai
• 机 构: LaboratoryofBlood-BorneVirusBeijingInstituteofTransfusionMedicine
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2010年44期
• 基金项目: Supported by The Natural Science Foundation of China,No.30600330,No.30671842,No.30672488,No.30700475,No.30771919and No.30700757,the National High Technology Research and Development Program of China,N

AIM:To develop a sensitive assay for screening compounds against hepatitis C virus (HCV).METHODS:The proteolytic cleavage of NS3/4A on enhanced yellow fluorescent protein (eYFP)-mitochondrial antiviral signaling protein (MAVS) was examined by reporter enz