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目前,罕见部位局限性纤维蛋白相关性EB病毒(EBV)阳性大B细胞增生淋巴瘤已有报道。本组12例患者中位年龄55.5岁,男女比为3∶1。12例纤维蛋白相关性EBV阳性大B细胞增生淋巴瘤中,镜下见淋巴瘤为偶发,包含3例心房黏液瘤,3例血管内移植物相关性血栓,2例慢性血肿和4例假性囊肿。病变均为非生发中心B细胞来源,Ⅲ型EBV潜伏期,FISH检测MYC重排和端粒交替延长均阴性。多数病例CD30,Ki-67和PD-L1均高表达,而MYC和p53均低
At present, rare localized fibrin-associated Epstein-Barr virus (EBV) -positive large B-cell lymphoma has been reported. The group of 12 patients with a median age of 55.5 years old, male to female ratio of 3: 1.12 cases of fibrin-related EBV-positive large B cell lymphoma, see the lymphoma sporadic microscope, including 3 cases of atrial myxoma, 3 Endovascular graft-associated thrombosis, 2 chronic hematomas, and 4 pseudocysts. The lesions were all non-germinal center B cell sources, type III EBV latency, FISH detection MYC rearrangement and telomere alternation were negative. Most cases of CD30, Ki-67 and PD-L1 were highly expressed, while MYC and p53 were low