Naofen promotes TNF-α-mediated apoptosis of hepatocytes by activating caspase-3 in lipopolysaccharid

• 作 者: Jun-Hua Fan Guo-Gang Feng Lei
• 机 构: DepartmentofGastroenterology,DepartmentofPharmacology,DepartmentofHepatobiliarySurgery
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2014年17期
• 关键词: Naofen TUMOR NECROSIS factor-α Apoptosis Lipopolys Naofen Tumor necrosis factor

AIM:To investigate whether naofen is involved in tumor necrosis factor(TNF)-α-mediated apoptosis of hepatocytes induced by lipopolysaccharide(LPS).METHODS:In vivo,rats were treated with LPS or antiTNF-αantibody,whereas in vitro,primary hepatocytes and Kup