表明小径的 ERK 1/2 和 STAT3 的激活为 661W 房间幸存追随者氧化剂损害被要求

• 作 者: Shu-Qian Dong Hui-Zhuo Xu Xiao
• 机 构: DepartmentofOphthalmology
• 出 处: 国际眼科杂志：英文版
• 发表日期: 2012年2期
• 关键词: 661W cells OXIDANT injury ERK1/2 STAT3 survival 661W cells oxidant injury ERK1/2
• 基金项目: National Natural Scientific Foundation of China (No. 81070752),PhD Innovation Program of Hunan Province, China (No. CX2010B106),Science and Technology Planning Project of Hunan Province, China (No. 20

AIM: To evaluate the influence of hydrogen peroxide (H2O2) on mouse photoreceptor-derived 661W cell survival and to determine the effect of PD98059, an inhibitor for MEK1 (the direct upstream activator of ERK1/2), and S3I201, a STAT3- specific inhibitor o