论文部分内容阅读
目的检测血浆D-二聚体、心肌损伤及N末端钠尿肽前体(NT-proBNP)标志物在主动脉夹层疾病中的变化情况,为筛查主动脉夹层和临床诊疗提供线索。方法收集2014年2月至2016年2月于秦皇岛市北戴河医院检查胸腹主动脉(CTA)的患者300例,根据检查结果分为非主动脉夹层疾病(100例)与主动脉夹层疾病(200例)两组。记录两组患者在治疗过程中血浆D-二聚体、心肌损伤[肌红蛋白、心肌型肌酸激酶同功酶(CKMB)]及NT-proBNP标志物、纤维蛋白降解产物(FDP)变化情况,并分析其相关性。结果主动脉夹层组患者D-二聚体、CKMB水平高于非主动脉夹层组,差异均有统计学意义(P<0.05);而性别、年龄、肌红蛋白、NT-proBNP、FDP在非主动脉夹层与主动脉夹层中差异无统计学意义(P>0.05)。相关性分析显示,主动脉夹层疾病的诊断与NT-proBNP标志物、CKMB、肌红蛋白的相关性不大,差异无统计学意义(P>0.05);而与D-二聚体、FDP具有一定的相关性,差异有统计学意义(P<0.05)。结论 D-二聚体、FDP与主动脉夹层疾病的诊断有一定相关性,对临床中快速简便诊断主动脉夹层有一定临床指导意义。
Objective To detect the changes of plasma D-dimer, myocardial injury and NT-proBNP markers in aortic dissection and to provide clues for the screening of aortic dissection and clinical diagnosis. Methods From February 2014 to February 2016, 300 patients with thoracoabdominal aorta (CTA) in Beidaihe Hospital of Qinhuangdao City were collected. According to the examination results, there were 300 cases of non-aortic dissection (100 cases) and 200 cases of aortic dissection Example) Two groups. The changes of plasma D-dimer, myocardial injury (myoglobin and cardiac muscle creatine kinase isoenzyme (CKMB)) and NT-proBNP markers and fibrin degradation products (FDP) were recorded during treatment , And analyze their relevance. Results The levels of D-dimer and CKMB in aortic dissection group were significantly higher than those in non-aortic dissection group (P <0.05), while gender, age, myoglobin, NT-proBNP and FDP There was no significant difference between aortic dissection and aortic dissection (P> 0.05). Correlation analysis showed that there was no significant difference between the diagnosis of aortic dissection and the NT-proBNP markers, CKMB and myoglobin (P> 0.05), but not with D-dimer A certain correlation, the difference was statistically significant (P <0.05). Conclusion D-dimer and FDP have some correlations with the diagnosis of aortic dissection, which is of clinical significance in clinical diagnosis of aortic dissection.