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目的探讨早孕妇女米非司酮药物流产与非药物人工流产的蜕膜组织中白血病抑制因子(LIF)表达的差异,分析米非司酮的致流产作用与LIF维持妊娠作用之间的关系。方法运用免疫组织化学技术检测23例米非司酮流产妇女蜕膜组织LIF蛋白的表达,并与20例非药物人工流产蜕膜组织进行对照。结果LIF蛋白在所有蜕膜标本中均有表达,其表达强度在米非司酮流产蜕膜组织和非药物人工流产蜕膜组织中无明显差异(P>0.05)。结论米非司酮对早孕蜕膜组织中LIF的表达可能无明显影响。
Objective To investigate the difference of leukemia inhibitory factor (LIF) expression in decidua between mifepristone abortion and non-drug induced abortion in early pregnant women and to analyze the relationship between abortion effect of mifepristone and the maintenance of pregnancy by LIF. Methods Immunohistochemical technique was used to detect the expression of LIF protein in decidua of 23 mifepristone abortion women and compared with 20 non-drug abortion decidua. Results The expression of LIF protein was detected in all deciduas. The expression level of LIF protein was not significantly different between decidua and non-drug abortion decidua in mifepristone abortion (P> 0.05). Conclusion Mifepristone may have no significant effect on the expression of LIF in early decidual tissue.