早期高血压患者的交感神经激活和一氧化氮功能

• 作 者: 刘莉 叶鹏
• 出 处: 中华高血压杂志
• 发表日期: 2012年07期
• 关键词: 一氧化氮 高血压 压力感受器反射 交感神经 交感神经节 交感神经活动 阻断剂 血压 Physiol 自主神经

Gamboa A,Okamoto LE,Diedrich A,Choi L,Robertson D,Farley G,Paranjape S,Biaggioni I.Am J Physiol Heart CircPhysiol,302(7):H1438-1443.该研究旨在探索高血压发生早期,通过一氧化氮抑制血压升高的功能是否受损。众所周知,一氧化氮功能受损会加快高血压进展,但这是一氧化氮对血管张力的直接作用还是间接通过调控交感神经活动起作用尚不清楚。该研究在应用交感神经节阻断剂咪噻吩去除压力感受器反射调控和一氧化氮对自主神经的调节作用后,

Gamboa A, Okamoto LE, Diedrich A, Choi L, Robertson D, Farley G, Paranjape S, Biaggioni I. Am J Physiol Heart Circ Physiol, 302 (7): H 1438-1443. The study aimed to explore the early stages of hypertension by Whether nitric oxide suppresses the function of raising blood pressure is damaged. It is well-known that impaired nitric oxide can accelerate the progression of hypertension, but whether this is the direct effect of nitric oxide on vascular tone or indirectly through the regulation of sympathetic activity remains unclear. In this study, after sympathetic ganglion blocker mothiophene was used to remove the baroreceptor reflex regulation and nitric oxide regulation of autonomic nervous system,