论文部分内容阅读
目的：通过对手术确诊为子宫内膜异位症的晚期患者进行女性性激素的测定，了解两者间的关系。方法：从妇科住院手术患者中，选择重度子宫内膜异位症患者作为对象，于滤泡期抽血测定促卵泡激素、促黄体生成素、垂体生乳激素、雌激素、孕激素、雄激素。根据术中所见病灶的部位、数目、大小和深度，按１９８５年美国生殖学会分期法给予评分，删除Ⅰ～Ⅲ期患者，晚期患者３５例。对照组４６例均来自门诊月经规则的健康妇女，于月经后一周抽静脉血作以上激素测定。结果：患病组体内的雌激素水平明显高于对照组（Ｐ＜０．０１），孕激素、雄激素、生乳素也高于对照组（Ｐ＜０．０５），促卵泡激素和促黄体生成素无明显变化（Ｐ＞０．０５）。患病组呈明显的内膜异位的病理改变，３５例中有２２例伴有子宫肌瘤（６２．９％）、５例伴有子宫内膜增生过长（１４．３％）。结论：重度（Ⅳ期）子宫内膜异位症患者体内雌激素水平明显增高，和孕激素、雄激素及垂体泌乳素有一定的关系，在高雌激素的环境下是否会引起子宫内膜异位症尚需进一步探讨
OBJECTIVE: To determine the relationship between the sex hormones in women with advanced endometriosis diagnosed by surgery. Methods: Patients with severe endometriosis were selected from gynecological inpatients and follicle stimulating hormone (FSH), luteinizing hormone (LH), pituitary prolactin, estrogen, progesterone and androgen were measured during follicular phase. According to the location of the lesions seen in surgery, the number, size and depth of the United States Society of Reproduction in 1985 according to the staging method to give the score, remove Ⅰ ~ Ⅲ patients, 35 patients with advanced disease. In the control group, 46 healthy women, all from outpatient menstrual rules, were given pheromone blood for one week after menstruation. Results: The level of estrogen in the sick group was significantly higher than that in the control group (P <0.01). The levels of progesterone, androgen and lactogen were also higher than those in the control group (P <0.05) There was no significant change in the hormone (P> 0.05). The diseased group showed obvious pathological changes of endometriosis, of which 35 cases, 22 cases with uterine fibroids (62.9%), 5 cases with endometrial hyperplasia (14.3%). Conclusion: The estrogen level in patients with severe endometriosis (Ⅳ stage) is significantly higher than that in patients with estrogen and progesterone, androgen and pituitary prolactin. Whether estrogen can cause endometriosis Disorders need to be further explored