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小脑在癫痫中作用的最早实验研究者是Risien Russell(1894),他注射艾酒(absinthe)入狗的颈静脉,从而定期产生全身性抽搐;切除半侧小脑后重复此实验时,发现切除的同侧肢体抽搐明显加重。1897年,Lowenthal和Horsloy以及Sherrington通过实验分别报告刺激小脑前叶皮质能够减轻去大脑强直。Dow等发现小脑对癫痫主要为抑制性影响。Ito和Yoshida证明小脑皮质的Purkinje细胞的整个输出放电是抑制性作用。Ito和Yoshida以及Dow等的研究建立了慢性小脑刺激(Cronic Cerebellar Stimulation CCS)的生理学
The earliest experimental investigator of the role of the cerebellum in epilepsy was Risien Russell (1894) who injected absinthe into the dog’s jugular vein to produce generalized convulsions on a regular basis. When the experiment was repeated after excision of the hemifacial cerebellum, the resected Ipsilateral limb twitch was significantly worse. In 1897, Lowenthal and Horsloy and Sherrington separately reported that stimulation of the anterior cerebellar lamina could reduce brain denervation. Dow et al found that the cerebellum had a predominantly suppressive effect on epilepsy. Ito and Yoshida demonstrate that the entire output discharge of Purkinje cells in the cerebellar cortex is an inhibitory effect. Studies by Ito and Yoshida and Dow et al. Established the physiology of Cronic Cerebellar Stimulation (CCS)