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目的分析艾滋病(AIDS)病人接受抗反转录病毒治疗后(ART)入院的常见原因。方法回顾性分析2005年1月至2009年2月,接受ART治疗后住院的艾滋病病例的临床资料。结果接受ART治疗的艾滋病住院病人共300人次,其中41.00%(123/300)、21.67%(65/300)、18.00%(54/300)和19.33%(58/300)的病人,分别在接受抗病毒治疗后半年内、半年到1年之间、1-2年间和治疗2年后入院。CD4细胞计数<200的病人占入院人数的80.14%(109/136),>200的占19.86%(27/136)。ART治疗半年内住院的原因,主要是ART的不良反应,占59.55%(53/89);治疗2年后住院的原因,机会性感染占20.68%(12/58)。单次入院的主要原因为:细菌、真菌感染占20.22%(18/89),药物性肝损13.48%(12/89),结核病8.99%(8/89)。多次入院的主要原因为:隐球菌脑膜炎复查28.91%(61/211),肿瘤化疗19.43%(41/211),结核病9.95%(21/211)。结论抗病毒药物的不良反应和机会性感染或肿瘤,是接受抗病毒治疗后病人入院的主要原因。降低药物不良反应,提高病人依从性,尽快重建机体的免疫功能,是减少病人入院的关键所在。
Objective To analyze the common causes of hospital admission of AIDS patients after receiving antiretroviral therapy (ART). Methods A retrospective analysis of clinical data of AIDS patients hospitalized after receiving ART treatment was retrospectively analyzed from January 2005 to February 2009. Results A total of 300 inpatients with AIDS were treated with ART. Among them, 41.00% (123/300), 21.67% (65/300), 18.00% (54/300) and 19.33% (58/300) Antiviral therapy within six months, six months to a year, 1-2 years and 2 years after admission. The patients with a CD4 count <200 accounted for 80.14% (109/136) of admission and 19.86% (27/136)> 200. The reasons for ART hospitalization within six months, mainly ART adverse reactions, accounting for 59.55% (53/89); hospitalized after 2 years of treatment reasons, opportunistic infections accounted for 20.68% (12/58). The main reasons for single admission were: bacterial, fungal infection accounted for 20.22% (18/89), drug-induced liver damage 13.48% (12/89), tuberculosis 8.99% (8/89). The main reasons for repeated admission were as follows: 28.91% (61/211) of recurrent cryptococcal meningitis, 19.43% (41/211) of chemotherapy, and 9.95% (21/211) of tuberculosis. Conclusion The adverse reactions of antiviral drugs and opportunistic infections or tumors are the main reasons for admission of patients after antiviral therapy. Reduce adverse drug reactions and improve patient compliance, as soon as possible to rebuild the body’s immune function, is to reduce the key to admission of patients.