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目的探讨血压节律变化对2型糖尿病(T2DM)患者下肢血管病变的影响。方法选取本院收治的120例T2DM患者进行观察,其中伴下肢血管病变患者60例设为观察组(LEAD组),另60例非下肢血管病变的2型糖尿病患者设为对照组(非LEAD组),两组患者实施24 h无创性动态血压监测,对两组患者的血压节律变化进行对比分析。结果与非LEAD组比较,LEAD组患者24 hSBP、24 hPP、nSBP、nPP上升、夜间血压下降率减少等血压节律出现改变,两组比较差异有统计学意义(P<0.05和P<0.01);非LEAD组患者杓型血压占68.33%,LEAD组杓型血压占36.67%,两组比较差异有统计学意义P<0.01;LEAD组患者起床晨峰血压和起床前晨峰血压明显高于对照组(P<0.05)。结论 T2DM患者下肢血管病变患者的昼夜血压变化强度大于非下肢血管病变患者,患者的夜间血压、血压晨峰均高于非下肢血管病变患者,下肢血管病变的危险性增加。
Objective To investigate the effect of changes in blood pressure rhythm on lower extremity vascular lesions in patients with type 2 diabetes mellitus (T2DM). Methods A total of 120 patients with T2DM admitted to our hospital were enrolled. 60 patients with lower extremity vascular disease were enrolled in the observation group (LEAD group), and the other 60 patients with non-lower extremity vascular disease were type 2 diabetic patients (non-LEAD group ). Non-invasive ambulatory blood pressure monitoring was performed on both groups 24 h after operation, and the changes of blood pressure rhythm in the two groups were compared. Results Compared with the non - LEAD group, the blood pressure rhythm of 24 hSBP, 24 hPP, nSBP and nPP in the LEAD group was significantly increased (P <0.05 and P <0.01). LEAD group patients with dipper blood pressure accounted for 68.33%, LEAD group dipper blood pressure accounted for 36.67%, the difference between the two groups was statistically significant P <0.01; LEAD patients wake morning peak blood pressure and morning before peak blood pressure was significantly higher than the control group (P <0.05). Conclusions The intensity of diurnal blood pressure changes of lower extremity vascular lesions in patients with T2DM is greater than that of non-lower extremity vascular diseases. The nighttime blood pressure and morning blood pressure of patients with T2DM are higher than those of non-lower extremity vascular diseases, and the risk of lower extremity vascular lesions is increased.