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本实验用３１Ｐ核磁共振谱仪，研究了短暂脑缺血对长期维持不同水平血糖的自发性糖尿病鼠脑内能量代谢、ｐＨ及再灌注后恢复的影响。结果发现，低血糖组（＜３ｍｍｏｌ／Ｌ）无机磷共振谱峰在缺血前高于其它各组，而ｐＨ的变化幅度最小。血糖为１３．７±１．２和２０．３±０．６ｍｍｏｌ／Ｌ的高血糖鼠，缺血引起的变化是相似的。缺血期间各组磷酸肌酸水平的下降无显著差别。脑组织ｐＨ的变化和高能磷酸化合物的水解，决定于缺血前的血糖水平。无机磷和ｐＨ的变化随着再灌注迅速恢复到缺血前的水平。然而，高血糖鼠磷酸肌酸水平并未完全恢复，其恢复程度决定于缺血前的血糖水平。本研究结果提示，正确地治疗糖尿病，可以减轻脑缺血引起的损害，这对于糖尿病人具有重要意义。
In this study, 31P nuclear magnetic resonance spectroscopy was used to investigate the effects of transient cerebral ischemia on brain energy metabolism, pH and recovery after reperfusion in spontaneous diabetic rats with long-term maintenance of different levels of blood glucose. The results showed that the inorganic phosphorus resonance peak of hypoglycemia group (<3mmol / L) was higher than that of other groups before ischemia, but the change of pH was the smallest. Blood glucose was 13.7 ± 1.2 and 20.3 ± 0.6mmol / L of hyperglycemic mice, the changes caused by ischemia were similar. There was no significant difference in the decrease of creatine phosphokate in each group during ischemia. Changes in brain tissue pH and the hydrolysis of high-energy phosphate compounds are determined by pre-ischemic blood glucose levels. Changes in inorganic phosphorus and pH quickly reverted to pre-ischemic levels following reperfusion. However, creatine phosphokate levels in hyperglycemic rats are not fully recovered, and the degree of recovery depends on pre-ischemic blood glucose levels. The results suggest that the correct treatment of diabetes, can reduce the damage caused by cerebral ischemia, which is of great significance for people with diabetes.