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骨钙素(BGP)是由成骨细胞分泌的一种非胶原蛋白,在调节骨钙的代谢方面起着十分重要的作用。BGP是评价骨形成状况的一项重要指标。本文报道甲亢、肝硬化、肝癌患者的血清骨钙素水平,并就其临床意义作初步探讨。 材料和方法 一、对象: (一)正常对照组:45例(男22,女23),年龄16～59岁,平均36岁。 (二)病人组:101例,均为本院门诊和住院病人。其中甲亢患者68例(男21,女47),年龄17～60岁,平均38岁;肝硬化患者18例(男11,女7),年龄31～62岁,平均45岁;肝癌患者15例(男8,女7),年龄28～54岁,平均43岁。 二、方法:受试对象上午空腹采静脉血,分离血清后-20℃保存待测。BGP RIA kit由解放军总医院东亚免疫技术研究所提供,操作按说明书。
Osteocalcin (BGP) is a non-collagen protein secreted by osteoblasts and plays an important role in the regulation of bone calcium metabolism. BGP is an important indicator to evaluate the status of bone formation. This paper reports serum osteocalcin levels in patients with hyperthyroidism, liver cirrhosis and liver cancer, and discusses its clinical significance. Materials and Methods 1. Object: (1) Normal control group: 45 cases (male 22, female 23), aged 16-59 years old, average 36 years old. (b) Patient group: 101 cases, both outpatient and inpatient in our hospital. Among them, 68 patients (21 males and 47 females) aged from 17 to 60 years old (mean 38 years old); 18 patients with liver cirrhosis (11 males and 7 females) aged 31 to 62 years with an average of 45 years; 15 patients with liver cancer (male 8, female 7), aged 28 to 54, with an average age of 43. 2. Methods: Subjects took venous blood on an empty stomach in the morning and separated the serum and stored them at -20°C. The BGP RIA kit is provided by the East Asian Institute of Immunology, General Hospital of PLA, and operated according to the instructions.