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本实验表明犬感染性休克时与氧自由基有关参数之间的变化存在一定关系。血浆丙二醛(MDA)升高与血中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性降低和血浆β-葡萄糖醛酸酶(β-GC)、血浆游离血红蛋白(PHb)升高呈正相关;β-GC升高与SOD,GSH-Px活性降低正相关,SOD活性降低与PHb升高正相关,存活时间与MDA,β-GC升高及SOD活性降低负相关(P<0.05或P<0.01)。结果提示氧自由基在感染性休克发病过程中起着重要作用,MDA、β-GC、SOD改变可作为判断感染性休克严重程度的指标。
This experiment shows that dogs with septic shock and oxygen free radicals related parameters between the changes in a certain relationship. Plasma malondialdehyde (MDA) and blood levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity decreased and plasma β-glucuronidase (β-GC), plasma Free radical hemoglobin (PHb) was positively correlated. The increase of β-GC was positively correlated with the decrease of SOD and GSH-Px activities. The decrease of SOD activity was positively correlated with the increase of PHb. The survival time, the increase of MDA and β-GC and the decrease of SOD activity Negative correlation (P <0.05 or P <0.01). The results suggest that oxygen free radicals plays an important role in the pathogenesis of septic shock. The changes of MDA, β-GC and SOD may be used as indexes to judge the severity of septic shock.