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目的 :研究Flt- 1,FGFR在胃癌中的表达及与MV计数的关系。方法 :以常规石蜡包埋切片ABC免疫组化法探讨 5 7例胃癌组织MV计数和Flt- 1,FGFR的表达情况。结果 :5 7例胃癌MV计数为 (47.6± 10 .5 )个 /HP ,Flt - 1、FGFR阳性率分别为 4 2 .1% (2 4 / 5 7)和 4 0 .4 % (2 3/ 5 7)。高分化胃癌MV计数明显低于低和 /或未分化和有淋巴结转移胃癌 ;无区域淋巴结转移胃癌Flt - 1、FGFR阳性率明显低于有区域淋巴结转移胃癌 ,均有显著性差异 (P <0 .0 5或P <0 .0 1)。MV计数和Flt - 1、FGFR阳性率呈密切正相关。结论 :MV计数、Flt- 1和FGFR表达与胃癌生物学行为、转移发生及预后有密切关系 ,Flt- 1和FGFR可作为胃癌预后的生物学标记物 ,对阳性病应加强术后的放疗和化疗
Objective: To study the relationship between the expression of Flt-1 and FGFR in gastric carcinoma and their relationship with the count of MV. Methods: The expression of Flt-1 and FGFR in 57 cases of gastric cancer tissues were studied by routine paraffin-embedded ABC immunohistochemistry. Results: The positive rate of Flt - 1 and FGFR in 47 patients with gastric cancer was (47.6 ± 10.5) / 47.4% (2 4/57) and 40.0% (2 3) respectively / 5 7). The MV counts of well differentiated gastric cancer were significantly lower than those of low and / or undifferentiated gastric cancer with lymph node metastasis. The positive rates of Flt - 1 and FGFR in gastric cancer without regional lymph node metastasis were significantly lower than those with regional lymph node metastasis (P <0 .0 5 or P <0 .0 1). The positive rate of Flt - 1 and FGFR was positively correlated with MV count. Conclusions: The expressions of Flt-1, FGFR and MV counts are closely related to the biological behavior, metastasis and prognosis of gastric cancer. Flt-1 and FGFR may be used as biomarkers for the prognosis of gastric cancer. Chemotherapy