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目的 探讨在宫内低水平铅暴露状态下 ,新生儿脐血铅含量及胎粪铅含量与神经行为发育的关系。方法 随机选取武汉市青山区第一冶金建筑总公司职工医院妇产科 1999年 1～ 10月出生的足月新生儿 10 3例。以脐血铅和胎粪铅含量作为新生儿宫内铅暴露的指标 ,新生儿神经行为发育评分作为效应指标。采用描述性分析方法评价其相关关系。脐血铅以 0 483μmol/L为界、胎粪铅以 12 7 78mg/kg为界 ,分别将研究对象分为高铅组与低铅组。结果 脐血高铅组与低铅组仅在新生儿神经行为发育总评分 (135 2 5与 40 0 3 5 )、生物视听定向反应 (1310 5与 40 45 5 )得分上差异有显著性 ,但脐血铅含量与新生儿神经行为发育总评分、非生物听定向反应、非生物视定向反应、生物视听定向反应之间不存在等级相关关系 ;而胎粪高铅组与低铅组在新生儿神经行为发育总评分(16 36 0与 3 72 0 0 )、非生物听定向反应 (2 110 5与 3 2 45 5 )、非生物视定向反应 (1836 0与 3 5 2 0 0 )、生物视听定向反应 (182 8 5与 3 5 2 7 5 ) 4项评分上 ,两组差异有显著性或非常显著性。胎粪铅含量与新生儿神经行为发育总评分、非生物视定向反应、生物视听定向反应 3项神经评分有明确的等级负相关关系。结论 胎粪铅含量可作为妊娠期胎儿体内
Objective To investigate the relationship between cord blood lead levels and fetal lead content and neurobehavioral development in neonates with low intrauterine lead exposure. Methods A total of 103 full-term newborns were randomly selected from the Department of Obstetrics and Gynecology, Staff Hospital of the First Metallurgical Construction Corporation, Qingshan District, Wuhan City from January to October in 1999. Umbilical cord blood lead and meconium as the lead content of neonatal lead exposure indicators, neonatal behavioral development score as an indicator of neurological. Using descriptive analysis method to evaluate the correlation. Umbilical cord blood lead to 0 483μmol / L as the boundary, meconium lead 12 7 78mg / kg for the community, respectively, the study was divided into high lead group and low lead group. Results There were significant differences in scores of neurological development (135 2 5 vs 40 0 3 5) and biologic audiovisual responses (1310 5 vs 40 45 5) in cord blood high lead group and low lead group only Umbilical cord blood lead and neonatal total score of neurobehavioral development, non-biological hearing-oriented response, non-biological visual response, biological audio-visual orientation does not exist between the level of correlation; and meconium high lead group and low lead group in newborns The total score of neurobehavioral development (16 36 0 vs 3 72 0 0), non-living audiometric responses (2 110 5 vs 3 2 45 5), and non-living visual responses (18 36 0 vs 35 2 0 0) There was significant or very significant difference between the two groups in the four scores of directional response (182 8 5 and 3 5 2 7 5). There was a clear negative correlation between the levels of lead in meconium and the three neurological scores of neonatal neurobehavioral development, non-biological visual response and biological visual response. Conclusion The content of fetal manure can be used as fetus during pregnancy