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目的调查湘中地区O型血孕妇血清IgG抗体效价与新生儿溶血病(HDN)发生率关系。方法采用微柱凝胶法抗人球蛋白试验,对550例丈夫为非O型血的孕妇在25～28周时检测其IgG抗体效价,对抗体效价≥1:64的孕妇每隔2～3周重复测1次效价,并对其分娩的320例A型或B型新生儿进行追踪调查。结果随着孕妇IgG抗体效价的升高,发生新生儿溶血的几率增高,并且IgG抗体动态升高2个或2个以上滴度时,新生儿溶血病发病率可达73%。结论孕妇IgG抗体效价与新生儿溶血病发生率成正相关,对O型血孕妇产前进行IgG抗体效价检测,并对高效价孕妇进行产前治疗是十分必要的。
Objective To investigate the relationship between serum IgG antibody titers and the incidence of neonatal hemolytic disease (HDN) in O type pregnant women in Central Hunan. Methods Using microcolumn gel anti-human globulin test, 550 pregnant women whose husband was non-O blood were tested for IgG antibody titers at 25-28 weeks. Pregnant women with antibody titers ≥1: 64 were randomly divided into 2 groups One titer was repeated ~ 3 weeks and 320 cases of type A or B infants born at the time of delivery were followed up. Results With the increase of IgG titer in pregnant women, the incidence of hemolysis in neonates was increased, and the incidence of hemolytic disease in neonates reached 73% when the IgG antibody was dynamically increased by 2 or more titers. Conclusions The titer of IgG antibody in pregnant women is positively correlated with the incidence of hemolytic disease in newborn. It is necessary to test the IgG antibody titer of prenatal O type pregnant women and prenatal treatment of high titer pregnant women.