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目的研究回族健康志愿者单次静脉滴注盐酸头孢吡肟后的药动学,并与汉族健康志愿者的药动学进行比较。方法回族和汉族健康志愿者各10名,男女各半,单次静脉滴注盐酸头孢吡肟1.0g,定时采血,用高效液相色谱法测定头孢吡肟的血药浓度,用DAS2.0软件进行数据处理,用SPSS11.5软件进行统计分析。结果两组药动学参数分别为:Cmax为(62.91±10.69)、(68.75±10.41)mg/L;t1/2β为(1.94±0.24)、(1.97±0.20)h;AUC(0-10.5)为(129.48±23.02)、(136.89±23.02)mg.h/L;AUC(0-∞)为(132.78±23.79)、(139.69±23.78)mg.h/L。结论头孢吡肟的药代动力学在回、汉两民族无种族差异。
Objective To study the pharmacokinetics of single-dose intravenous cefepime in healthy volunteers of Hui nationality and to compare the pharmacokinetics with healthy volunteers in Han nationality. Methods A total of 10 healthy volunteers were enrolled in this study. Each male and female were divided into two groups. 1.0 g of cefepime hydrochloride was injected intravenously and blood was collected periodically. Plasma concentration of cefepime was determined by high performance liquid chromatography (DAS2.0) Data processing, using SPSS11.5 software for statistical analysis. Results The pharmacokinetic parameters of the two groups were (62.91 ± 10.69) and (68.75 ± 10.41) mg / L respectively, and the values of t1 / 2β were (1.94 ± 0.24) and (1.97 ± 0.20) (129.48 ± 23.02) and (136.89 ± 23.02) mg.h / L respectively; AUC (0-∞) was (132.78 ± 23.79) and (139.69 ± 23.78) mg.h / L, respectively. Conclusion The pharmacokinetics of cefepime has no racial difference between Hui and Han peoples.