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食管癌相关基因4(ECRG4/C2ORF40)被认为是一种与预后相关的候选抑癌基因,它在多种肿瘤中都有涉及,包括食管鳞状细胞瘤、前列腺癌、乳腺癌、结直肠癌以及神经胶质瘤。其启动子的高甲基化可能是该基因表达下调的主要原因。因此恢复ECRG4在肿瘤中的表达有可能成为肿瘤治疗的一种新的有效途径。
Esophageal cancer-associated gene 4 (ECRG4 / C2ORF40) is considered as a prognostic candidate tumor suppressor gene and is involved in a variety of tumors including esophageal squamous cell carcinoma, prostate cancer, breast cancer, colorectal cancer As well as gliomas. Hypermethylation of its promoter may be the main reason for the down-regulation of this gene. Therefore, to restore the expression of ECRG4 in the tumor may become a new and effective approach for the treatment of cancer.