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测定了不同月龄组（６、１２、１８和２４）大鼠离体肝脏枯否细胞（ＫＣ）葡萄糖利用能力和线粒体的能量代谢状态，以及维生素Ｅ（ＶＥ）对这种状态的影响。结果表明，１８月龄组和２４月龄组肝脏ＫＣ葡萄糖利用能力和线粒体能量代谢明显低于６月龄组，前者分别为６月龄组的８０．７％和６４．９％，后者分别为８０．５％和６７．９％。１８月龄和２４月龄ＶＥ治疗组葡萄糖利用能力和线粒体能量代谢状态均有明显改善，并以１８月龄组最明显，两者分别为正常对照的９４．７％和９７．３％。结果提示，老化对ＫＣ葡萄糖利用能力和线粒体能量代谢具有明显的负影响，ＶＥ对这种影响具有较好的预防作用。
The ability of glucose utilization and the energy metabolism of mitochondria in isolated rat liver Kupffer cells (KC) and the effect of Vitamin E (VE) on this condition were measured in different month groups (6,12,18 and 24). The results showed that the hepatic KC glucose utilization and mitochondrial energy metabolism of 18-month-old and 24-month-old mice were significantly lower than those of 6-month-old mice, the former were 80.7% and 64.9% 80.5% and 67.9%. The 18-month-old and 24-month-old VE treatment groups showed a significant improvement in glucose utilization and mitochondrial energy metabolism, most notably in the 18-month-old group, 94.7% and 97.3% of the normal controls, respectively. The results suggest that aging has a significant negative impact on KC glucose utilization and mitochondrial energy metabolism, and VE has a good preventive effect on this effect.