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至1953年3月止的6个月期间,作者曾用异菸醯肼治疗了175例结核患者,其中有11例患者发生了多发性神经炎(6%)。异菸醯肼每日剂量为每公斤体重10毫克。此种神经炎颇似毒性神经炎,患者有感觉异常,皮肤温度改变及排汗功能障碍,趾端与指端常有针刺感及蚁行感。历数周後,上述诸症状更趋明显,同时足底有烧灼感。先有双手无力;继而累及双足。在少数几个病例中有轻度感觉过敏及多汗症。在某些病例中反射及运动神经功能正常,但一般均有腱反射消失,触、痛、热、位置及震颤感亦受影响,因而产生不完全麻痹。运动障碍的程度与感觉障碍的
During the 6 months to March 1953, the authors treated 175 TB patients with isoniazid, and 11 of them developed polyneuritis (6%). Isoniazid daily dose of 10 mg per kilogram of body weight. Such neuritis is similar to toxic neuritis, patients have abnormal sensations, skin temperature changes and perspiration dysfunction, toe and fingertips often feel acupuncture and sense of ants. After several weeks, the above symptoms become more apparent, while there is burning sensation in the bottom of the foot. First, both hands weakness; then involving feet. In a few cases there is mild sensory hypersensitivity and hyperhidrosis. Reflexes and motor nerves are normal in some cases, but tendon reflexes generally disappear. Contact, pain, heat, location and tremor are also affected, resulting in incomplete paralysis. The degree of dyskinesia and sensory disturbances