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目的 研究老年人po司帕沙星片的药动学特点。方法 用HPLC测定 8例老年人po 2 0 0mg司帕沙星片后 12 0h内血样和尿样中司帕沙星浓度 ,采用 3P87药动学程序对血药浓度 时间数据进行线性拟合 ,计算药动学参数。根据尿药浓度和尿量计算该药尿原型药物排泄率。结果 本实验建立的HPLC线性关系、回收率、日内及日间精密度均能满足药动学研究的要求 ,老年人 po司帕沙星片后血药浓度 时间数据符合二室模型 ,主要药动学参数为t1/ 2 β=(2 6 .11± 6 .4 9)h ,tmax=(2 .74±1.4 2 )h ,cmax=(1.15± 0 .14 )mg·L-1,AUC0～∞ =(37.2 9± 11.17)mg·h·L-1。服药后 12 0h平均尿原型药物排泄率为2 4 .14 %。结论 老年人半衰期达 2 6h ,单剂 po 2 0 0mg 4 8h后血药浓度均高于绝大多数细菌的MIC及MBC ,一般感染可考虑 3d 2次或 2d 1次给药
Objective To study the pharmacokinetics of po sparfloxacin tablets in the elderly. Methods Serum and urine samples of sparfloxacin were determined by HPLC after 8 months old po po 2000mg sparfloxacin tablets. The concentration of sparfloxacin in plasma and urine samples was linearly fitted by 3P87 pharmacokinetic program. Pharmacokinetic parameters. Calculate the urinary excretion rate of the drug according to the urinary drug concentration and urine output. Results The HPLC linear relationship, recovery rate, intra-day and intra-day precision established by this experiment could meet the requirements of pharmacokinetic study. The data of blood plasma concentration of po sparfloxacin in elderly patients accorded with two-compartment model and the main pharmacokinetics The parameters of the study were t1 / 2β = (21.6 ± 6.14) h, tmax = (2.74 ± 1.4 2) h, cmax = (1.15 ± 0.14) mg · L -1, AUC0 ~ ∞ = (37.2 9 ± 11.17) mg · h · L-1. The mean urinary excretion rate was 12.4% after 120 h. Conclusion The half-life of the elderly up to 26h, single-dose po 20 0mg 4 8h plasma concentrations were higher than the MIC and MBC of most bacteria, the general infection can be considered 3d 2 or 1 d administration