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目的:研究体外受精-胚胎移植(IVF-ET)术后早期自然流产的相关因素。方法:回顾性分析我中心2009年1～12月经过IVF-ET治疗后获得临床妊娠的393例患者的临床资料。根据其妊娠结局分为流产组和对照组,比较两组的年龄、窦卵泡数、促排卵药物(Gn)使用总量、Gn使用天数、获卵数、胚胎数、优胚数和移植胚胎数。结果:流产组患者的年龄高于对照组(P<0.05);而两组间窦卵泡数、Gn使用总量、Gn使用天数、获卵数、胚胎数、优胚数和移植胚胎数比较,差异无统计学意义(P>0.05)。结论:IVF-ET术后早期自然流产的发生与患者年龄有关。加强对高龄不孕患者的监测,尽可能采取保胎措施,对防止IVF-ET术后早期自然流产的发生具有积极意义。
Objective: To study the related factors of early spontaneous abortion after in vitro fertilization-embryo transfer (IVF-ET). Methods: The clinical data of 393 patients who received clinical pregnancy after treatment with IVF-ET from January to December in our hospital from 2009 to December were retrospectively analyzed. According to their pregnancy outcomes were divided into abortion group and control group. The age, antral follicle count, total amount of ovulation induction drug (Gn), days of Gn use, number of oocytes retrieved, number of embryos, number of excellent embryos and number of embryos transferred . Results: The age of patients in the abortion group was higher than that in the control group (P <0.05). The number of follicles in the abortion group, the total Gn usage, the days of Gn use, the number of oocytes retrieved, the number of embryos, The difference was not statistically significant (P> 0.05). Conclusion: The incidence of early spontaneous abortion after IVF-ET is related to patient’s age. To strengthen the monitoring of elderly patients with infertility, as far as possible to take child-arrest measures to prevent the occurrence of early spontaneous abortion after IVF-ET has a positive significance.