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目的本研究探讨显像评估帕金森病严重程度的意义。方法对15例对照者和30例帕金森病患者(根据Hoehn-Yahr分级分为早期组18例,中晚期组12例)行99mTc-TRODAT-1DATSPECT断层显像,注射示踪剂2~3h后采集图像,勾画出感兴趣区(双侧纹状体和枕叶),计算机自动计算感兴趣区的放射性计数,最后测算出纹状体与枕叶部位的放射性计数比值和非对称性指数,并进行比较分析。结果对照组特异性放射性计数比值是0.58±0.16(左侧)、0.56±0.32(右侧),早期帕金森病组特异性放射性计数比值为0.40±0.33(症状对侧或症状严重肢体对侧)、0.51±0.12(症状同侧),中晚期帕金森病组特异性放射性计数比值为0.23±0.18(症状严重肢体对侧)、0.40±0.17(症状同侧);对照组非对称性指数是5.12±0.48,早期帕金森病组为9.05±14.61,中晚期组为20.67±14.2,3组间比较均有显著性差异(P<0.05)。结论多巴胺转运体99mTc-TRODAT-1SPECT显像有助于帕金森病严重程度的判断。
Purpose This study explored the significance of imaging in assessing the severity of Parkinson’s disease. Methods 99mTc-TRODAT-1 DATSPECT imaging was performed in 15 controls and 30 Parkinson’s disease patients (18 according to Hoehn-Yahr classification, 12 patients in early-stage group) and 2 to 3 hours after tracer injection Collecting images, delineating regions of interest (bilateral striatum and occipital lobe), computer automatically calculate the area of interest radioactive count, and finally calculate the striatum and occipital lobe radioactive count ratio and asymmetry index For comparative analysis. Results The ratio of specific radioactivity counts in control group was 0.58 ± 0.16 (left) and 0.56 ± 0.32 (right), and the specific radioactivity count in early Parkinson’s disease group was 0.40 ± 0.33 (contralateral or symptomatic severe contralateral) , 0.51 ± 0.12 (ipsilateral), and the ratio of specific radioactive count in late stage of Parkinson’s disease group was 0.23 ± 0.18 (contralateral severe limbs), 0.40 ± 0.17 (ipsilateral); the index of asymmetry in control group was 5.12 ± 0.48, early stage Parkinson’s disease group was 9.05 ± 14.61, middle and late stage group was 20.67 ± 14.2, 3 groups were significantly different (P <0.05). Conclusion dopamine transporter 99mTc-TRODAT-1 SPECT imaging contributes to determine the severity of Parkinson’s disease.