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目的系统评价ALOX5AP基因SG13S89多态性与中国人缺血性脑卒中的相关性。方法计算机检索Web of Science、Pub Med、CNKI、CBM、EMbase和Wan Fang Data数据库,搜集与ALOX5AP基因SG13S89多态性与缺血性脑卒中发生的相关性研究,检索时限均为建库至2016年10月。由2名研究者独立进行文献筛选、资料提取和评价纳入研究的偏倚风险评价后,采用STATA 12.0进行Meta分析。结果共纳入11个病例-对照研究。Meta分析结果显示ALOX5AP基因SG13S89多态性与中国人缺血性脑卒中发病风险增加相关[A vs.G:OR=1.192,95%CI(1.029,1.381),P=0.019;AA+AG vs.GG:OR=1.20,95%CI(1.029,1.400),P=0.020;AG vs.GG:OR=1.195,95%CI(1.022,1.397),P=0.025]。结论 ALOX5AP基因SG13S89多态性与中国人缺血性脑卒中有关,A等位基因是其潜在危险因素。
Objective To evaluate the association between ALOX5AP gene SG13S89 polymorphism and ischemic stroke in Chinese. Methods We searched the databases of Web of Science, Pub Med, CNKI, CBM, EMbase and Wan Fang Data for the study of the association between ALOX5AP gene SG13S89 polymorphism and ischemic stroke. October. Two investigators independently screened the literature, data were extracted and evaluated for inclusion in the study after the risk assessment of bias was performed using a meta-analysis of STATA 12.0. Results A total of 11 case-control studies were included. Meta analysis showed that ALOX5AP gene SG13S89 polymorphism was associated with an increased risk of ischemic stroke in China [A vs. G: OR = 1.192, 95% CI (1.029, 1.381), P = 0.019; AA + AG vs. GG: OR = 1.20, 95% CI (1.029, 1.400), P = 0.020; AG vs.GG: OR = 1.955, 95% CI (1.022, 1.397), P = .025]. Conclusion The ALOX5AP gene SG13S89 polymorphism is associated with ischemic stroke in Chinese. The A allele is a potential risk factor.