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服用大剂量的氯氮平出现癫痫发作在国内、外均有报告,而缓慢撤药引起持续性癫痫发作者国内外均未见报告,但对这一戒断症状的认识不足,可造成诊断和处理的困难。现将本院1例报告如下。患者,女,20岁,因精神分裂症4年于1985年首次门诊治疗,先后服舒必利、奋乃静均无效,故于2年前改用氯氮平50mg Bid,逐渐加至600mg/日,维持治疗3个月,精神症状缓解,此后开始减量,每隔5天减量25mg,因家属欲改服中药维持治疗,而在3个月内减完,停药第15天,晚上看电视时,突然倒地,手
Epilepsy occurred in both high and low doses of clozapine at home and abroad, while there was no report at home and abroad about the slow withdrawal of clozapine. However, lack of knowledge about this symptom of withdrawal may result in the diagnosis and Processing difficulties. Now one of the hospital reported as follows. Patients, female, 20 years old, first outpatient treatment for schizophrenia for 4 years in 1985, has served sulpiride, perphenazine were invalid, so 2 years ago switched to clozapine 50mg Bid, gradually increased to 600mg / day, Maintained treatment for 3 months, mental symptoms, and then began to reduce, every 5 days weight reduction 25mg, due to family members want to change to maintain traditional Chinese medicine treatment, and within 3 months by the end of withdrawal 15 days, watching TV at night Suddenly fell to the ground, hands