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[目的]观察NO吸入对急性肺栓塞实验性家兔心肌钙蛋白的影响。[方法]30只家兔随机分为对照组:常规溶栓治疗+蒸馏水吸入组(A组,15只)和治疗组:常规溶栓治疗+NO吸入组(B组,15只),吸入NO浓度为40×10-6g/L。按照自体血凝块法制作家兔急性肺栓塞模型。栓塞后除常规溶栓治疗外即刻两组分别吸入等量蒸馏水和NO,于栓塞前(T1),栓塞后2h(T2)、4h(T3)、12h(T4)、24h(T5)、36h(T6)时抽取动脉血用化学分光法测定血清心肌肌钙蛋白I(cTnI)的浓度。[结果]两组的血清cTnI的浓度在T2、T3、T4、T5、T6时刻均比T1时显著增高(P﹤0.01),组间比较A组的血清cTnI升高幅度明显高于B组(P﹤0.01)。[结论]NO吸入对家兔急性肺栓塞后的心肌损伤有保护作用。
[Objective] To observe the effect of NO inhalation on experimental cardiac troponin in acute pulmonary embolism in rabbits. [Methods] Thirty rabbits were randomly divided into control group: conventional thrombolysis + distilled water inhalation group (group A, n = 15) and treatment group: conventional thrombolytic therapy + NO inhalation group The concentration is 40 × 10-6g / L. Rabbit acute pulmonary embolism model was made according to autologous blood clot method. Immediately before embolization (T1), 2h (T2), 4h (T3), 12h (T4), 24h (T5), 36h T6), the concentration of serum cardiac troponin I (cTnI) was determined by chemical spectrophotometry. [Results] The levels of serum cTnI in both groups were significantly higher than those at T1 at T2, T3, T4, T5 and T6 (P <0.01). The increase of serum cTnI in group A was significantly higher than that in group B P <0.01). [Conclusion] NO inhalation has a protective effect on myocardial injury after acute pulmonary embolism in rabbits.