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以鼠抗人 OKT_3、OKT_4、OKT _8三种单克隆抗体检测37例进展型胃癌及23例SLE 患者的外周血中 T 细胞及其亚群细胞的百分值,并计算 OKT_4/OKT_8细胞的百分比值。结果发现胃癌组表现为 OKT_4细胞的降低,OKT_8细胞的增高,OKT_4/OKT_8比值降低,仅为1.2±0.4。其中晚期胃癌组30例中此改变尤为突出,OKT_4/OKT_8比值仅为1.12±0.3(与正常对照2.1±0.5相比,P<0.001)。活动型 SLE 患者正与胃癌组相反,表现为 OKT_8细胞的降低,仅为18.5±4.1%,因而 OKT_4/OKT_8比值增高为3.0±0.5。随着治疗后病情好转,OKT_8细胞恢复正常,而 OKT_4细胞降低(可能与肾上腺皮质激素有关),因而 OKT_4/OKT_8比值反有降低。
OKT_3, OKT_4, OKT_8 and OKT_8 were used to detect the percentages of T cells and their subpopulations in 37 patients with advanced gastric cancer and 23 patients with SLE. The percentages of OKT_4 / OKT_8 cells were calculated value. The results showed OKT_4 cells decreased OKT_4 cells in gastric cancer group, OKT_8 cells increased, OKT_4 / OKT_8 ratio decreased to only 1.2 ± 0.4. In 30 cases of advanced gastric cancer, the change was particularly prominent. The ratio of OKT_4 / OKT_8 was only 1.12 ± 0.3 (P <0.001 compared with the normal control 2.1 ± 0.5). In patients with active SLE, as opposed to the gastric cancer group, OKT_8 cells showed a decrease of only 18.5 ± 4.1%, thus increasing the OKT_4 / OKT_8 ratio to 3.0 ± 0.5. OKT_8 cells returned to normal and OKT_4 cells decreased (possibly related to adrenocorticotropic hormone) as the condition improved after treatment, so the OKT_4 / OKT_8 ratio was inversely decreased.