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目的观察人工肝血浆置换(PE)治疗重型肝炎的临床疗效及安全性。方法采用日本CHF-10血浆净化治疗机、AFP血浆分离器,进行血浆置换治疗各期重型肝炎89例,未经PE治疗的各期重型肝炎76例为对照组,比较两组相同治疗时期的近期疗效。结果治疗组每次治疗后症状、精神、食欲、体力均有明显改变,TBIL、DBIL、ALT、AST、PT、PTA均明显好转。治疗组早、中期有效率分别为85.71%、71.87%,分别高于对照组的36.84%、65.38%,两组比较差异有统计学意义(P<0.01),未发现不良反应。结论应用人工肝血浆置换治疗重型肝炎具有一定疗效,且早、中期的疗效较晚期好。
Objective To observe the clinical efficacy and safety of artificial liver plasma exchange (PE) in the treatment of severe hepatitis. Methods 89 cases of severe hepatitis treated by plasma exchange were treated with Japanese plasma decontamination machine CHF-10 and AFP plasma separator. 76 cases of severe hepatitis without PE were used as the control group. The patients in the same treatment period were compared Efficacy. Results The symptoms, spirit, appetite and physical strength of the treatment group were significantly changed after each treatment. The TBIL, DBIL, ALT, AST, PT and PTA were all significantly improved. The early and mid-term effective rates in the treatment group were 85.71% and 71.87%, respectively, which were higher than those in the control group (36.84% and 65.38% respectively). There was significant difference between the two groups (P <0.01). No adverse reactions were found. Conclusion The application of artificial liver plasmapheresis in the treatment of severe hepatitis has some curative effect, and the early and mid-term curative effect is better than the late.