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系统性红斑狼疮(SLE)系一自体免疫性疾患,病因尚未阐明。本文介绍有关遗传学说和病毒学说的若干最新资料。 1972年,在日本进行了全国SLE普查。估计全国SLE患者总数约6300～8500名。即每10万人口中有6.6～8.5个患者。据美国1950年普查,发病率为2/10万;最近普查,发病率为19～50/10万。 SLE的遗传学说有下列依据: 1.患者家族内SLE发病率的研究据Block等(1975)报告,患者第一代亲属中SLE发病率为1.5％。比上述一般人口中发病率大大升高。强烈显示患者家族中有容易罹患SLE的遗传素质在起作用。据日本国内统计,有3～5％
Systemic lupus erythematosus (SLE) is an autoimmune disease, the etiology has not been elucidated. This article introduces some of the latest information on genetics and virus theory. In 1972, a national SLE survey was conducted in Japan. It is estimated that the total number of SLE patients nationwide is about 6,300 to 8,500. That is 6.6 to 8.5 patients per 100,000 population. According to the United States 1950 census, the incidence was 2 / 100,000; the recent census, the incidence was 19 to 50 / 100,000. The genetic basis of SLE is based on the following criteria: 1. Study of the incidence of SLE in a patient’s family According to Block et al. (1975), the incidence of SLE in the first-generation relatives of patients was 1.5%. The incidence is much higher than the above general population. It is strongly suggested that genetic predisposition to SLE in the patient’s family is at work. According to Japan’s domestic statistics, 3 to 5%