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本文报告了慢性肺原性心脏病急性发作期患者肺弥散功能障碍时,血浆粘度对肺摄氧能力的影响。A-aDo_2分别为20—30mmHg和大于30mmHg的两组病例,当血浆比粘度(ηρ)分别小于理想值1.85和1.95时,Pao_2/PAo_2比值与血浆比粘度呈正相关,其相关系数分别为0.598和0.869;血浆比粘度分别大于理想值时,Pao_2/PAo_2比值与血浆比粘度呈负相关,其相关系数分别为-0.886和-0.635;而A-aDo_2在正常范围的一组病人,其Pao_2/PAo_2比值则与血浆比粘度无关(γ=0.041,P>0.05)。作者对上述现象的机理作了探讨,提示对于慢性肺心病患者,血浆粘度的重要性不仅在于影响全血粘度和红细胞的聚集性,在影响肺微循环血流方面,也有自己独立的作用。
This article reports the effect of plasma viscosity on lung oxygen uptake in patients with diffuse lung dysfunction during acute episodes of chronic pulmonary heart disease. When the plasma specific viscosity (ηρ) was less than the ideal value of 1.85 and 1.95 respectively, the Pao_2 / PAo_2 ratio had a positive correlation with the plasma specific viscosity with the correlation coefficients of 0.598 and 0.869, respectively. The correlation coefficients of Pao_2 / PAo_2 and plasma specific viscosity were -0.886 and -0.635, respectively. However, the Pao_2 / PAo_2 values in a group of patients with A-aDo_2 in the normal range were significantly lower than those in the normal range The ratio was not related to plasma specific viscosity (γ = 0.041, P> 0.05). The authors discussed the mechanism of the above phenomena, suggesting that for patients with chronic cor pulmonale, the importance of plasma viscosity not only affects the viscosity of whole blood and the aggregation of erythrocytes, but also has its own independent role in influencing the blood flow in the pulmonary microcirculation.