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为研究叶下珠属植物台湾细叶油柑体内外抗乙肝病毒的作用 ,应用 2 115细胞株及雏鸭乙型肝炎模型 ,对台湾细叶油柑水提取物和醇提取物进行了体内外抗乙肝活性实验。结果 :台湾细叶油柑水提取物和醇提取物对HBsAg分泌均有一定抑制作用 ,但其醇提物对HBeAg的分泌无抑制作用。在体内抗鸭乙肝病毒实验中 ,台湾细叶油柑水提物 10g·kg- 1·d- 1和 5g·kg- 1·d- 1剂量组于给药 5d、给药 10d和停药 3d时有显著体内抑制DHBV -DNA作用 ,而其醇提物则无抑制DHBV -DNA作用。提示台湾细叶油柑水提取物有抗乙肝病毒作用
In order to study the anti-hepatitis B virus activity in leaves of Mentha genus in Taiwan and in vitro and in vivo, the 2115 cell line and the duckling hepatitis B model were used to perform in vitro and in vivo extractions of water extracts and alcohol extracts from Taiwan oleander. Anti-hepatitis B activity experiment. RESULTS : The extracts of water extract and alcohol extracts from Taiwanese mangosteen had a certain inhibitory effect on the secretion of HBsAg, but their alcohol extracts had no inhibitory effect on the secretion of HBeAg. In the anti-duck hepatitis B virus test in vivo, the 10g·kg-1 ·d-1 and 5g·kg-1 ·d-1 doses of Taiwanese mangosteen water extract were administered for 5 days, administered for 10 days, and stopped for 3 days. There was significant inhibition of DHBV-DNA in vivo, while its alcohol extract did not inhibit DHBV-DNA. Tips that the extract of Taiwan Olea oleifera has anti-hepatitis B virus effect