Synthesis of N-(methoxycarbonyl or isopropylcarbamoyl- methoxyphosphonyl)-α-amino acid ester and the

• 作 者: 陈茹玉 李慧英
• 机 构: Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China,Institute of Eleme
• 出 处: Science in China,Ser.B
• 发表日期: 1996年04期
• 关键词: esters isomers starting carbonyl separated constants Synthesis of N stirring ove

N-(methoxycarbonyl-methoxyphosphonyl)-α-amino add esters (I) were synthesized via the reaction of the corresponding phosphonyl chloride with amino acid ester hydrochlorides in the presence of a base. Compound I was aminated to yield N-(isopropylcarbainoyl-methoxyphosphonyl)-α-amino acid esters (II). With l-amino acids as starting materials, the isomers of products I and II were separated and their configurations were confirmed by the single crystal X-ray diffraction of II.