糖皮质激素抵抗的可能分子机制

• 作 者: 聂蔚 陈玉霞
• 机 构: 第二军医大学学员旅1队,第二军医大学病理生理学教研室 上海200433,上海200433
• 出 处: 国外医学(生理、病理科学与临床分册)
• 发表日期: 2004年03期
• 关键词: 糖皮质激素 抵抗 分子机制

糖皮质激素是治疗过敏性疾病的常用药物 ,但许多疾病都存在糖皮质激素抵抗的现象。糖皮质激素抵抗的机制可能发生在受体前或受体水平 ,牵涉到免疫反应异常激活、激素代谢异常、受体基因突变或磷酸化异常、受体的变异体异常增多、受体与其他蛋白如AP 1和STAT5等发生相互作用等环节。

Glucocorticoids are commonly used drugs to treat allergic diseases, but glucocorticoid resistance exists in many diseases. The mechanism of glucocorticoid resistance may occur at the level of pre-receptor or receptor, involving abnormal activation of immune response, abnormal hormone metabolism, abnormal gene mutation or phosphorylation of receptor, abnormal increase of receptor variant, interaction between receptor and other proteins Such as AP 1 and STAT5 and other aspects of interaction.