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目的研究脑梗死相关蛋白在评估急性脑梗死(ACI)患者脑血管狭窄程度中的作用。方法选取2010-2012年在珠江医院因ACI住院的患者,选取脑动脉造影结果狭窄程度>70%及闭塞者为试验组(n=29),≤70%者及正常者为对照组(n=23)。检测所有患者外周血脑梗死相关蛋白含量。结果试验组患者超敏C反应蛋白(hs-CRP)、血栓前体蛋白(TpP)、脂蛋白α(Lpα)外周血中含量分别为(3.51±2.25)mg/L、(1797.08±162.35)μg/L、(363.81±218.34)mg/L,均较对照组明显升高,差异有统计学意义(P<0.05)。D-二聚体(DDI)、纤维蛋白原(Fg)、血小板凝聚因子(vWF)的含量无明显变化。hs-CRP(P=0.029,OR=2.232)、TpP(P=0.032,OR=1.014)、Lpα(P=0.024,OR=1.009)与脑大动脉粥样硬化病变导致的脑血管狭窄程度相关,DDI(P=0.671)、Fg(P=0.248)、vWF(P=0.090)与脑血管的狭窄程度相关性不明显。高血压(P=0.029,OR=4.582)是脑血管狭窄的危险因素。结论 hs-CRP、TpP、Lpα、高血压是脑大动脉粥样硬化病变导致的ACI患者脑血管重度狭窄的危险因素,血清中hs-CRP、TpP、Lpα含量升高同时伴有高血压的ACI患者脑血管重度狭窄的可能性增大。
Objective To study the role of cerebral infarction related proteins in assessing the degree of cerebrovascular stenosis in patients with acute cerebral infarction (ACI). Methods Patients with ACI hospitalized in Zhujiang Hospital from 2010 to 2012 were enrolled in this study. The degree of stenosis of cerebral artery angiography (> 70%) and those with occlusion (n = 29), ≤70% and normal controls were selected as control group (n = twenty three). All patients with peripheral blood infarction related protein content. Results The peripheral blood levels of hs-CRP, TpP and Lpα in the test group were (3.51 ± 2.25) mg / L, (1797.08 ± 162.35) μg /L, (363.81 ± 218.34) mg / L, were significantly higher than the control group, the difference was statistically significant (P <0.05). D-dimer (DDI), fibrinogen (Fg), platelet aggregation factor (vWF) content did not change significantly. The levels of hs-CRP (P = 0.029, OR = 2.232), TpP (P = 0.032, OR = 1.014) and Lpα (P = 0.024, OR = 1.009) were correlated with the degree of cerebrovascular stenosis caused by cerebral atherosclerosis. DDI (P = 0.671), Fg (P = 0.248), vWF (P = 0.090) and the degree of cerebrovascular stenosis. Hypertension (P = 0.029, OR = 4.582) was a risk factor for cerebrovascular stenosis. Conclusions hs-CRP, TpP, Lpα and hypertension are the risk factors of severe cerebrovascular stenosis caused by cerebral atherosclerosis in patients with ACI. Serum levels of hs-CRP, TpP and Lpα are also associated with hypertension in ACI patients The possibility of severe cerebrovascular stenosis increases.