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氟喹诺酮类抗菌物是近(?)0年发展起来的新型抗生素,具有广谱、高效、易透过细胞外膜、毒性低、使用简便、价格便宜等优点,目前已广泛应用于临床,其抗感势作用堪与头孢类抗生素媲美。从1988年我院首先使用新合成第三代氟喹诺酮类抗生素氟哌酸(NFLO),替代新霉素防治自体骨髓移植(ABMT)中肠源性细菌感染。迄今已成功地防治13例,在“骨髓空虚期”无1例发生感染,保证ABMT
Fluoroquinolone antibacterials are new antibiotics developed in recent 0 years. They are broad-spectrum, high-efficiency, easy to penetrate the outer membrane, low toxicity, easy to use and cheap, and have been widely used clinically Resistance to anti-sensitive effect comparable to cephalosporins. From 1988 our hospital first use of new synthetic third-generation fluoroquinolone antibiotics norfloxacin (NFLO), instead of neomycin to prevent autologous bone marrow transplantation (ABMT) midgut-derived bacterial infection. So far, 13 cases have been successfully controlled and no infection occurred in the “bone marrow empty phase”, ensuring that ABMT